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Genome-wide association study of response to tumour necrosis factor inhibitor therapy in rheumatoid arthritis

Rheumatoid arthritis (RA) is characterised by chronic synovial joint inflammation. Treatment has been revolutionised by tumour necrosis factor alpha inhibitors (TNFi) but each available drug shows a significant non-response rate. We conducted a genome-wide association study of 1752 UK RA TNFi-treate...

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Detalles Bibliográficos
Autores principales: Massey, Jonathan, Plant, Darren, Hyrich, Kimme, Morgan, Ann W., Wilson, Anthony G., Spiliopoulou, Athina, Colombo, Marco, McKeigue, Paul, Isaacs, John, Cordell, Heather, Pitzalis, Costantino, Barton, Anne
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6150911/
https://www.ncbi.nlm.nih.gov/pubmed/30166627
http://dx.doi.org/10.1038/s41397-018-0040-6