Cargando…

Microglia prevent peripheral immune cell invasion and promote an anti-inflammatory environment in the brain of APP-PS1 transgenic mice

BACKGROUND: Undoubtedly, neuroinflammation is a major contributor to Alzheimer’s disease (AD) progression. Neuroinflammation is characterized by the activity of brain resident glial cells, in particular microglia, but also by peripheral immune cells, which infiltrate the brain at certain stages of d...

Descripción completa

Detalles Bibliográficos
Autores principales:	Unger, M. S., Schernthaner, P., Marschallinger, J., Mrowetz, H., Aigner, L.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2018
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6151006/ https://www.ncbi.nlm.nih.gov/pubmed/30241479 http://dx.doi.org/10.1186/s12974-018-1304-4

Ejemplares similares

Microglia depletion diminishes key elements of the leukotriene pathway in the brain of Alzheimer’s Disease mice
por: Michael, J., et al.
Publicado: (2020)

Immune-mediated platelet depletion augments Alzheimer’s disease neuropathological hallmarks in APP-PS1 mice
por: de Sousa, Diana M. Bessa, et al.
Publicado: (2023)

Early Changes in Hippocampal Neurogenesis in Transgenic Mouse Models for Alzheimer’s Disease
por: Unger, M. S., et al.
Publicado: (2016)

Effects of (−)Epicatechin on the Pathology of APP/PS1 Transgenic Mice
por: Zeng, Yue-Qin, et al.
Publicado: (2014)

Microglia Express Insulin-Like Growth Factor-1 in the Hippocampus of Aged APP(swe)/PS1(ΔE9) Transgenic Mice
por: Myhre, Christa Løth, et al.
Publicado: (2019)

The blockage of the Nogo/NgR signal pathway in microglia alleviates the formation of Aβ plaques and tau phosphorylation in APP/PS1 transgenic mice
por: Fang, Yinquan, et al.
Publicado: (2016)

Studies on APP metabolism related to age-associated mitochondrial dysfunction in APP/PS1 transgenic mice
por: Chen, Lizhi, et al.
Publicado: (2019)

Dysregulation of Na+/K+ ATPase by amyloid in APP+PS1 transgenic mice
por: Dickey, Chad A, et al.
Publicado: (2005)

Tanshinone IIA Alleviates the AD Phenotypes in APP and PS1 Transgenic Mice
por: Li, Fengling, et al.
Publicado: (2016)

The effects of treadmill exercise on autophagy in hippocampus of APP/PS1 transgenic mice
por: Zhao, Na, et al.
Publicado: (2018)

Platelets in Amyloidogenic Mice Are Activated and Invade the Brain
por: Kniewallner, Kathrin M., et al.
Publicado: (2020)

Vaccine Development to Treat Alzheimer's Disease Neuropathology in APP/PS1 Transgenic Mice
por: Carrera, Iván, et al.
Publicado: (2012)

Electroacupuncture decreases cognitive impairment and promotes neurogenesis in the APP/PS1 transgenic mice
por: Li, Xuying, et al.
Publicado: (2014)

Naringin Dihydrochalcone Ameliorates Cognitive Deficits and Neuropathology in APP/PS1 Transgenic Mice
por: Yang, Wenjuan, et al.
Publicado: (2018)

Deposition of BACE-1 Protein in the Brains of APP/PS1 Double Transgenic Mice
por: Luo, Gang, et al.
Publicado: (2016)

Lipid droplet accumulating microglia represent a dysfunctional and pro-inflammatory state in the aging brain
por: Marschallinger, Julia, et al.
Publicado: (2020)

Effects of Curculigoside on Memory Impairment and Bone Loss via Anti-Oxidative Character in APP/PS1 Mutated Transgenic Mice
por: Zhao, Lu, et al.
Publicado: (2015)

Treadmill Exercise Ameliorates Adult Hippocampal Neurogenesis Possibly by Adjusting the APP Proteolytic Pathway in APP/PS1 Transgenic Mice
por: Yu, Haizhen, et al.
Publicado: (2021)

Contribution of genetic and dietary insulin resistance to Alzheimer phenotype in APP/PS1 transgenic mice
por: Hiltunen, Mikko, et al.
Publicado: (2012)

Synaptic Changes in the Dentate Gyrus of APP/PS1 Transgenic Mice Revealed by Electron Microscopy
por: Alonso-Nanclares, Lidia, et al.
Publicado: (2013)

Abnormalities of plasma cytokines and spleen in senile APP/PS1/Tau transgenic mouse model
por: Yang, Seung-Hoon, et al.
Publicado: (2015)

Effects and Mechanism of Huannao Yicong Decoction Extract on the Ethology of Transgenic APP/PS1 Mice
por: Liu, Meixia, et al.
Publicado: (2017)

Untargeted lipidomics reveals progression of early Alzheimer’s disease in APP/PS1 transgenic mice
por: Zhang, Xueju, et al.
Publicado: (2020)

Effects of Peppermint Essential Oil on Learning and Memory Ability in APP/PS1 Transgenic Mice
por: Lv, Xiaofan, et al.
Publicado: (2022)

Immunocytochemical Characterization of Alzheimer Disease Hallmarks in APP/PS1 Transgenic Mice Treated with a New Anti-Amyloid-β Vaccine
por: Carrera, Iván, et al.
Publicado: (2013)

Immunocytochemical Characterization of Alzheimer’s Disease Hallmarks in APP/PS1 Transgenic Mice Treated with a New Anti-Amyloid-β Vaccine
por: Carrera, Ivan, et al.
Publicado: (2014)

Rapid and sustained cognitive recovery in APP/PS1 transgenic mice by co-administration of EPPS and donepezil
por: Kim, Hye Yun, et al.
Publicado: (2016)

Humulus japonicus inhibits the progression of Alzheimer's disease in a APP/PS1 transgenic mouse model
por: Park, Tae-Shin, et al.
Publicado: (2017)

Effects of Oligosaccharides From Morinda officinalis on Gut Microbiota and Metabolome of APP/PS1 Transgenic Mice
por: Xin, Yang, et al.
Publicado: (2018)

Ligustilide Ameliorates Memory Deficiency in APP/PS1 Transgenic Mice via Restoring Mitochondrial Dysfunction
por: Xu, Yi-Jun, et al.
Publicado: (2018)

Fecal microbiota transplantation alleviated Alzheimer’s disease-like pathogenesis in APP/PS1 transgenic mice
por: Sun, Jing, et al.
Publicado: (2019)

Effect of the electro-acupuncture on senile plaques and its formation in APP(+)/PS1(+) double transgenic mice
por: Yang, Qinghua, et al.
Publicado: (2018)

Zerumbone ameliorates behavioral impairments and neuropathology in transgenic APP/PS1 mice by suppressing MAPK signaling
por: Li, Lei, et al.
Publicado: (2020)

Jatrorrhizine Balances the Gut Microbiota and Reverses Learning and Memory Deficits in APP/PS1 transgenic mice
por: Wang, Sheng, et al.
Publicado: (2019)

Ovocystatin Induced Changes in Expression of Alzheimer’s Disease Relevant Proteins in APP/PS1 Transgenic Mice
por: Stanczykiewicz, Bartlomiej, et al.
Publicado: (2022)

Effects of Qi-Fu-Yin on aging of APP/PS1 transgenic mice by regulating the intestinal microbiome
por: Xiao, Qiu-yue, et al.
Publicado: (2023)

APP21 transgenic rats develop age-dependent cognitive impairment and microglia accumulation within white matter tracts
por: Weishaupt, Nina, et al.
Publicado: (2018)

Extracellular Vesicles Can Deliver Anti-inflammatory and Anti-scarring Activities of Mesenchymal Stromal Cells After Spinal Cord Injury
por: Romanelli, Pasquale, et al.
Publicado: (2019)

VIP Enhances Phagocytosis of Fibrillar Beta-Amyloid by Microglia and Attenuates Amyloid Deposition in the Brain of APP/PS1 Mice
por: Song, Min, et al.
Publicado: (2012)

(-)-Epigallocatechin-3-gallate ameliorates learning and memory impairments by attenuating peroxidation in APP/PS1 transgenic mice
por: Liu, Mingyan, et al.
Publicado: (2012)

Cannot write session to /tmp/vufind_sessions/sess_hd9veb0h36jitmhqjvuenb53mk