Polymorphisms in Cytochrome P450 are associated with Extensive Efavirenz Pharmacokinetics and CNS Toxicities in an HIV Cohort in Botswana

Inter-individual variability in efavirenz (EFV) pharmacokinetics and dynamics are dominantly driven by the polymorphism in cytochrome P450 (CYP) isoenzyme 2B6 516G>T. We hypothesized that additional CYP polymorphisms mediate the relationship between CYP2B6 516G>T, EFV metabolism, and clinical...

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Detalles Bibliográficos
Autores principales: Vujkovic, Marijana, Bellamy, Scarlett L., Zuppa, Athena F., Gastonguay, Marc R., Moorthy, Ganesh S, Ratshaa, Bakgaki, Han, Xiaoyan, Steenhoff, Andrew P., Mosepele, Mosepele, Strom, Brian L., Bisson, Gregory P., Aplenc, Richard, Gross, Robert
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6151142/
https://www.ncbi.nlm.nih.gov/pubmed/29855606
http://dx.doi.org/10.1038/s41397-018-0028-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6151142/
https://www.ncbi.nlm.nih.gov/pubmed/29855606
http://dx.doi.org/10.1038/s41397-018-0028-2

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