Potential role of PIN1 genotypes in predicting benefit from oxaliplatin- and irinotecan-based treatment in patients with metastatic colorectal cancer

PIN1-mediated substrate isomerization plays a role in the repair of DNA double-strand breaks. We hypothesized that genetic polymorphisms in PIN1-related pathways may affect tumor sensitivity to oxaliplatin or irinotecan in metastatic colorectal cancer (mCRC) patients. We analyzed genomic DNA from fi...

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Detalles Bibliográficos
Autores principales: Suenaga, Mitsukuni, Schirripa, Marta, Cao, Shu, Zhang, Wu, Yang, Dongyun, Cremolini, Chiara, Lonardi, Sara, Bergamo, Francesca, Ning, Yang, Yamamoto, Noriko, Okazaki, Satoshi, Berger, Martin D., Miyamoto, Yuji, Gopez, Roel, Barzi, Afsaneh, Yamaguchi, Toshiharu, Stintzing, Sebastian, Heinemann, Volker, Loupakis, Fotios, Falcone, Alfredo, Lenz, Heinz-Josef
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6151284/
https://www.ncbi.nlm.nih.gov/pubmed/29925895
http://dx.doi.org/10.1038/s41397-018-0030-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6151284/
https://www.ncbi.nlm.nih.gov/pubmed/29925895
http://dx.doi.org/10.1038/s41397-018-0030-8

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