Solvent-Free Addition of Indole to Aldehydes: Unexpected Synthesis of Novel 1-[1-(1H-Indol-3-yl) Alkyl]-1H-Indoles and Preliminary Evaluation of Their Cytotoxicity in Hepatocarcinoma Cells

New 1-[1-(1H-indol-3-yl) alkyl]-1H-indoles, surprisingly, have been obtained from the addition of indole to a variety of aldehydes under neat conditions. CaO, present in excess, was fundamental for carrying out the reaction with paraformaldehyde. Under the same reaction conditions, aromatic and hete...

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Detalles Bibliográficos
Autores principales: Tocco, Graziella, Zedda, Gloria, Casu, Mariano, Simbula, Gabriella, Begala, Michela
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6151463/
https://www.ncbi.nlm.nih.gov/pubmed/29039799
http://dx.doi.org/10.3390/molecules22101747

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6151463/
https://www.ncbi.nlm.nih.gov/pubmed/29039799
http://dx.doi.org/10.3390/molecules22101747

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