From 2-Alkylsulfanylimidazoles to 2-Alkylimidazoles: An Approach towards Metabolically More Stable p38α MAP Kinase Inhibitors

In vitro and in vivo metabolism studies revealed that 2-alkylsulfanylimidazole ML3403 (4-(5-(4-fluorophenyl)-2-(methylthio)-1H-imidazol-4-yl)-N-(1-phenylethyl)pyridin-2-amine) undergoes rapid oxidation to the sulfoxide. Replacing the sulfur atom present in the two potent p38α mitogen-activated prote...

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Detalles Bibliográficos
Autores principales: Heider, Fabian, Haun, Urs, Döring, Eva, Kudolo, Mark, Sessler, Catharina, Albrecht, Wolfgang, Laufer, Stefan, Koch, Pierre
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6151569/
https://www.ncbi.nlm.nih.gov/pubmed/29036906
http://dx.doi.org/10.3390/molecules22101729

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6151569/
https://www.ncbi.nlm.nih.gov/pubmed/29036906
http://dx.doi.org/10.3390/molecules22101729

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