Methylisoindigo and Its Bromo-Derivatives Are Selective Tyrosine Kinase Inhibitors, Repressing Cellular Stat3 Activity, and Target CD133+ Cancer Stem Cells in PDAC

Indirubin is an active component of the herbal ingredient ‘Danggui Longhui wan’, which was used for the treatment of inflammation and chronic myeloid leukemia in China. The recent study showed its derivative methylisoindigo (also known as meisoindigo) preferentially targeting cancer stem cells (CSCs...

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Detalles Bibliográficos
Autores principales: Tegethoff, Jana, Bischoff, Roland, Saleh, Sawsan, Blagojevic, Biljana, Merz, Karl-Heinz, Cheng, Xinlai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6151689/
https://www.ncbi.nlm.nih.gov/pubmed/32961646
http://dx.doi.org/10.3390/molecules22091546

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6151689/
https://www.ncbi.nlm.nih.gov/pubmed/32961646
http://dx.doi.org/10.3390/molecules22091546

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