Novel Selective Estrogen Receptor Ligand Conjugates Incorporating Endoxifen-Combretastatin and Cyclofenil-Combretastatin Hybrid Scaffolds: Synthesis and Biochemical Evaluation

Nuclear receptors such as the estrogen receptors (ERα and ERβ) modulate the effects of the estrogen hormones and are important targets for design of innovative chemotherapeutic agents for diseases such as breast cancer and osteoporosis. Conjugate and bifunctional compounds which incorporate an ER li...

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Detalles Bibliográficos
Autores principales: Kelly, Patrick M., Keely, Niall O., Bright, Sandra A., Yassin, Bassem, Ana, Gloria, Fayne, Darren, Zisterer, Daniela M., Meegan, Mary J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6151695/
https://www.ncbi.nlm.nih.gov/pubmed/28858267
http://dx.doi.org/10.3390/molecules22091440

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6151695/
https://www.ncbi.nlm.nih.gov/pubmed/28858267
http://dx.doi.org/10.3390/molecules22091440

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