Novel FXa Inhibitor Identification through Integration of Ligand- and Structure-Based Approaches

Factor Xa (FXa), a vitamin K-dependent serine protease plays a pivotal role in the coagulation cascade, one of the most interesting targets for the development of new anticoagulants. In the present work, we performed a virtual screening campaign based on ligand-based shape and electrostatic similari...

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Detalles Bibliográficos
Autores principales: Lagos, Carlos F., Segovia, Gerardine F., Nuñez-Navarro, Nicolás, Faúndez, Mario A., Zacconi, Flavia C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6151700/
https://www.ncbi.nlm.nih.gov/pubmed/28937618
http://dx.doi.org/10.3390/molecules22101588

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6151700/
https://www.ncbi.nlm.nih.gov/pubmed/28937618
http://dx.doi.org/10.3390/molecules22101588

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