Coordination Mechanism and Bio-Evidence: Reactive γ-Ketoenal Intermediated Hepatotoxicity of Psoralen and Isopsoralen Based on Computer Approach and Bioassay

Psoralen and isopsoralen are secondary plant metabolites found in many fruits, vegetables, and medicinal herbs. Psoralen-containing plants (Psoralea corylifolia L.) have been reported to cause hepatotoxicity. Herein, we found that psoralen and isopsoralen were oxidized by CYP450s to reactive furanoe...

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Detalles Bibliográficos
Autores principales: Hai, Yue, Feng, Shan, Wang, Lili, Ma, Yetao, Zhai, Yiran, Wu, Zijun, Zhang, Sichao, He, Xin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6151710/
https://www.ncbi.nlm.nih.gov/pubmed/32962321
http://dx.doi.org/10.3390/molecules22091451

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6151710/
https://www.ncbi.nlm.nih.gov/pubmed/32962321
http://dx.doi.org/10.3390/molecules22091451

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