Design, Modeling and Synthesis of 1,2,3-Triazole-Linked Nucleoside-Amino Acid Conjugates as Potential Antibacterial Agents

Copper-catalyzed azide-alkyne cycloadditions (CuAAC or click chemistry) are convenient methods to easily couple various pharmacophores or bioactive molecules. A new series of 1,2,3-triazole-linked nucleoside-amino acid conjugates have been designed and synthesized in 57–76% yields using CuAAC. The a...

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Detalles Bibliográficos
Autores principales: Malkowski, Sarah N., Dishuck, Carolyn F., Lamanilao, Gene G., Embry, Carter P., Grubb, Christopher S., Cafiero, Mauricio, Peterson, Larryn W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
Materias:
Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6151744/
https://www.ncbi.nlm.nih.gov/pubmed/28994722
http://dx.doi.org/10.3390/molecules22101682

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6151744/
https://www.ncbi.nlm.nih.gov/pubmed/28994722
http://dx.doi.org/10.3390/molecules22101682

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