Effects of P-Glycoprotein on the Transport of DL0410, a Potential Multifunctional Anti-Alzheimer Agent

In our study, we attempted to investigate the influences of P-glycoprotein (P-gp) on DL0410, a novel synthetic molecule for Alzheimer’s disease (AD) treatment, for intestinal absorption and blood-brain barrier permeability in vitro and related binding mechanisms in silico. Caco-2, MDCK, and MDCK-MDR...

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Detalles Bibliográficos
Autores principales: Pang, Xiaocong, Wang, Lin, Kang, De, Zhao, Ying, Wu, Song, Liu, Ai-Lin, Du, Guan-Hua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6151990/
https://www.ncbi.nlm.nih.gov/pubmed/28757552
http://dx.doi.org/10.3390/molecules22081246

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6151990/
https://www.ncbi.nlm.nih.gov/pubmed/28757552
http://dx.doi.org/10.3390/molecules22081246

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