Time- and NADPH-Dependent Inhibition on CYP3A by Gomisin A and the Pharmacokinetic Interactions between Gomisin A and Cyclophosphamide in Rats

The traditional Chinese medicine Schisandra chinensis has remarkable protective effects against chemical-induced toxicity. Cyclophosphamide (CTX), in spite advances in chemotherapy and immunosuppressive regimes, is prone to cause severe toxicity due to its chloroacetaldehyde (CAA) metabolite produce...

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Detalles Bibliográficos
Autores principales: Zhai, Jianxiu, Zhang, Feng, Gao, Shouhong, Chen, Li, Feng, Ge, Yin, Jun, Chen, Wansheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6152024/
https://www.ncbi.nlm.nih.gov/pubmed/28786954
http://dx.doi.org/10.3390/molecules22081298

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6152024/
https://www.ncbi.nlm.nih.gov/pubmed/28786954
http://dx.doi.org/10.3390/molecules22081298

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