Synthesis and Identification of Novel Berberine Derivatives as Potent Inhibitors against TNF-α-Induced NF-κB Activation

Twenty-three new berberine (BBR) analogues defined on substituents of ring D were synthesized and evaluated for their activity for suppression of tumor necrosis factor (TNF)-α-induced nuclear factor (NF)-κB activation. Structure–activity relationship (SAR) analysis indicated that suitable tertiary/q...

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Detalles Bibliográficos
Autores principales: Wang, Yan-Xiang, Liu, Lu, Zeng, Qing-Xuan, Fan, Tian-Yun, Jiang, Jian-Dong, Deng, Hong-Bin, Song, Dan-Qing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6152030/
https://www.ncbi.nlm.nih.gov/pubmed/28749438
http://dx.doi.org/10.3390/molecules22081257

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6152030/
https://www.ncbi.nlm.nih.gov/pubmed/28749438
http://dx.doi.org/10.3390/molecules22081257

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