Lactose Binding Induces Opposing Dynamics Changes in Human Galectins Revealed by NMR-Based Hydrogen–Deuterium Exchange

Galectins are β-galactoside-binding proteins implicated in a myriad of biological functions. Despite their highly conserved carbohydrate binding motifs with essentially identical structures, their affinities for lactose, a common galectin inhibitor, vary significantly. Here, we aimed to examine the...

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Detalles Bibliográficos
Autores principales: Chien, Chih-Ta Henry, Ho, Meng-Ru, Lin, Chung-Hung, Hsu, Shang-Te Danny
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6152064/
https://www.ncbi.nlm.nih.gov/pubmed/28813004
http://dx.doi.org/10.3390/molecules22081357

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6152064/
https://www.ncbi.nlm.nih.gov/pubmed/28813004
http://dx.doi.org/10.3390/molecules22081357

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