(15)N-, (13)C- and (1)H-NMR Spectroscopy Characterization and Growth Inhibitory Potency of a Combi-Molecule Synthesized by Acetylation of an Unstable Monoalkyltriazene

6-(3-Methyltriaz-1-en-1-yl)-1H-benzo[de]isoquinoline-1,3(2H)-dione referred to as EG22 (8a), is an open-chain 3-alkyl-1,2,3-triazene termed “combi-molecule” designed to inhibit poly(adenosine diphosphate ribose) polymerase (PARP) and damage DNA. To delay its hydrolysis, acetylation of N3 was require...

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Detalles Bibliográficos
Autores principales: Senhaji Mouhri, Zhor, Goodfellow, Elliot, Kelley, Steven P., Stein, Robin S., Rogers, Robin D., J. Jean-Claude, Bertrand
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6152079/
https://www.ncbi.nlm.nih.gov/pubmed/28753938
http://dx.doi.org/10.3390/molecules22071183

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6152079/
https://www.ncbi.nlm.nih.gov/pubmed/28753938
http://dx.doi.org/10.3390/molecules22071183

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