Cargando…
Mechanism Exploration of Arylpiperazine Derivatives Targeting the 5-HT(2A) Receptor by In Silico Methods
As a G-protein coupled receptor, the 5-hydroxytryptamine 2A (5-HT(2A)) receptor is known for its critical role in the cognitive, behavioural and physiological functions, and thus is a primary molecular target to treat psychiatric diseases, including especially depression. With purpose to explore the...
Autores principales: | Lin, Feng, Li, Feng, Wang, Chao, Wang, Jinghui, Yang, Yinfeng, Yang, Ling, Li, Yan |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2017
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6152085/ https://www.ncbi.nlm.nih.gov/pubmed/28672848 http://dx.doi.org/10.3390/molecules22071064 |
Ejemplares similares
-
Design, Synthesis and Biological Activity Evaluation of Arylpiperazine Derivatives for the Treatment of Neuropathic Pain
por: Chen, Yin, et al.
Publicado: (2011) -
Synthesis, in vitro and in vivo evaluation of (11)C-O-methylated arylpiperazines as potential serotonin 1A (5-HT(1A)) receptor antagonist radiotracers
por: Narayanaswami, Vidya, et al.
Publicado: (2020) -
Synthesis, bioactivity, and molecular docking of novel arylpiperazine derivatives as potential AR antagonists
por: Qi, Yueheng, et al.
Publicado: (2022) -
Synthesis, Docking Studies and Biological Evaluation of Benzo[b]thiophen-2-yl-3-(4-arylpiperazin-1-yl)-propan-1-one Derivatives on 5-HT(1A) Serotonin Receptors
por: Pessoa-Mahana, Hernán, et al.
Publicado: (2012) -
Profiling the Interaction Mechanism of Quinoline/Quinazoline Derivatives as MCHR1 Antagonists: An in Silico Method
por: Wu, Mingwei, et al.
Publicado: (2014)