Insights into the Effect of the G245S Single Point Mutation on the Structure of p53 and the Binding of the Protein to DNA

The transcription factor p53 is a potent tumor suppressor dubbed as the “guardian of the genome” because of its ability to orchestrate protective biological outputs in response to a variety of oncogenic stresses. Mutation and thus inactivation of p53 can be found in 50% of human tumors. The majority...

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Detalles Bibliográficos
Autores principales: Lepre, Marco Gaetano, Omar, Sara Ibrahim, Grasso, Gianvito, Morbiducci, Umberto, Deriu, Marco Agostino, Tuszynski, Jack A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6152093/
https://www.ncbi.nlm.nih.gov/pubmed/28813011
http://dx.doi.org/10.3390/molecules22081358

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6152093/
https://www.ncbi.nlm.nih.gov/pubmed/28813011
http://dx.doi.org/10.3390/molecules22081358

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