Evaluation of Novel Dual Acetyl- and Butyrylcholinesterase Inhibitors as Potential Anti-Alzheimer’s Disease Agents Using Pharmacophore, 3D-QSAR and Molecular Docking Approaches

DL0410, containing biphenyl and piperidine skeletons, was identified as an acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE) inhibitor through high-throughput screening assays, and further studies affirmed its efficacy and safety for Alzheimer’s disease treatment. In our study, a series...

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Detalles Bibliográficos
Autores principales: Pang, Xiaocong, Fu, Hui, Yang, Shilun, Wang, Lin, Liu, Ai-Lin, Wu, Song, Du, Guan-Hua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6152156/
https://www.ncbi.nlm.nih.gov/pubmed/28933746
http://dx.doi.org/10.3390/molecules22081254

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6152156/
https://www.ncbi.nlm.nih.gov/pubmed/28933746
http://dx.doi.org/10.3390/molecules22081254

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