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Evaluation of Novel Dual Acetyl- and Butyrylcholinesterase Inhibitors as Potential Anti-Alzheimer’s Disease Agents Using Pharmacophore, 3D-QSAR and Molecular Docking Approaches

DL0410, containing biphenyl and piperidine skeletons, was identified as an acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE) inhibitor through high-throughput screening assays, and further studies affirmed its efficacy and safety for Alzheimer’s disease treatment. In our study, a series...

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Detalles Bibliográficos
Autores principales:	Pang, Xiaocong, Fu, Hui, Yang, Shilun, Wang, Lin, Liu, Ai-Lin, Wu, Song, Du, Guan-Hua
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6152156/ https://www.ncbi.nlm.nih.gov/pubmed/28933746 http://dx.doi.org/10.3390/molecules22081254

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