An Efficient One-Pot Catalyzed Synthesis of 2,4-Disubstituted 5-Nitroimidazoles Displaying Antiparasitic and Antibacterial Activities

A one-pot regioselective bis-Suzuki-Miyaura or Suzuki-Miyaura/Sonogashira reaction on 2,4-dibromo-1-methyl-5-nitro-1H-imidazole under microwave heating was developed. This method is applicable to a wide range of (hetero)arylboronic acids and terminal alkynes. Additionally, this approach provides a s...

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Detalles Bibliográficos
Autores principales: Mathias, Fanny, Kabri, Youssef, Okdah, Liliane, Di Giorgio, Carole, Rolain, Jean-Marc, Spitz, Cédric, Crozet, Maxime D., Vanelle, Patrice
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6152245/
https://www.ncbi.nlm.nih.gov/pubmed/28771219
http://dx.doi.org/10.3390/molecules22081278

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6152245/
https://www.ncbi.nlm.nih.gov/pubmed/28771219
http://dx.doi.org/10.3390/molecules22081278

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