Cargando…

Molecular Dynamics Simulations of the Host Defense Peptide Temporin L and Its Q3K Derivative: An Atomic Level View from Aggregation in Water to Bilayer Perturbation

Temporin L (TempL) is a 13 residue Host Defense Peptide (HDP) isolated from the skin of frogs. It has a strong affinity for lipopolysaccharides (LPS), which is related to its high activity against Gram-negative bacteria and also to its strong tendency to neutralize the pro-inflammatory response caus...

Descripción completa

Detalles Bibliográficos
Autores principales:	Farrotti, Andrea, Conflitti, Paolo, Srivastava, Saurabh, Ghosh, Jimut Kanti, Palleschi, Antonio, Stella, Lorenzo, Bocchinfuso, Gianfranco
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6152314/ https://www.ncbi.nlm.nih.gov/pubmed/28737669 http://dx.doi.org/10.3390/molecules22071235

Ejemplares similares

The Influence of pH on the Scleroglucan and Scleroglucan/Borax Systems
por: Mazzuca, Claudia, et al.
Publicado: (2017)

Synergistic Antibacterial and Anti-Inflammatory Activity of Temporin A and Modified Temporin B In Vivo
por: Capparelli, Rosanna, et al.
Publicado: (2009)

Antibacterial and Antibiofilm Activity of Temporin-GHc and Temporin-GHd Against Cariogenic Bacteria, Streptococcus mutans
por: Zhong, Hengren, et al.
Publicado: (2019)

Aggregation and Its Influence on the Bioactivities of a Novel Antimicrobial Peptide, Temporin-PF, and Its Analogues
por: Zai, Yu, et al.
Publicado: (2021)

Rheoreversible hydrogels in paper restoration processes: a versatile tool
por: Mazzuca, Claudia, et al.
Publicado: (2014)

Cell-Selective Pore Forming Antimicrobial Peptides of the Prodomain of Human Furin: A Conserved Aromatic/Cationic Sequence Mapping, Membrane Disruption, and Atomic-Resolution Structure and Dynamics
por: Sinha, Sheetal, et al.
Publicado: (2018)

Temporins: Multifunctional Peptides from Frog Skin
por: D’Andrea, Luca Domenico, et al.
Publicado: (2023)

Induction of a Diverse T Cell Receptor γ/δ Repertoire by the Helix-Loop-Helix Proteins E2a and Heb in Nonlymphoid Cells
por: Ghosh, Jimut Kanti, et al.
Publicado: (2001)

Temporin B Forms Hetero-Oligomers with Temporin L, Modifies Its Membrane Activity, and Increases the Cooperativity of Its Antibacterial Pharmacodynamic Profile
por: Ferguson, Philip M., et al.
Publicado: (2022)

Scleroglucan: A Versatile Polysaccharide for Modified Drug Delivery
por: Coviello, Tommasina, et al.
Publicado: (2005)

Functional Characterization of Temporin-SHe, a New Broad-Spectrum Antibacterial and Leishmanicidal Temporin-SH Paralog from the Sahara Frog (Pelophylax saharicus)
por: André, Sonia, et al.
Publicado: (2020)

Aggregation of Aß(25-35) on DOPC and DOPC/DHA Bilayers: An Atomic Force Microscopy Study
por: Sublimi Saponetti, Matilde, et al.
Publicado: (2014)

Four temporin-derived peptides exhibit antimicrobial and antibiofilm activities against methicillin-resistant Staphylococcus aureus : Anti-MRSA peptides derived from temporin
por: Tan, Xiuchuan, et al.
Publicado: (2022)

Temporin-GHb of Hylarana guentheri induces apoptosis by the mitochondrial pathway in MDA-MB-231 cells : Temporin-GHb induces MDA-MB-231 cell apoptosis
por: Liu, Yujun, et al.
Publicado: (2022)

Antibiofilm Properties of Temporin-L on Pseudomonas fluorescens in Static and In-Flow Conditions
por: Di Somma, Angela, et al.
Publicado: (2020)

Temporin-SHa and Its Analogs as Potential Candidates for the Treatment of Helicobacter pylori
por: Olleik, Hamza, et al.
Publicado: (2019)

The Bactericidal Activity of Temporin Analogues Against Methicillin Resistant Staphylococcus aureus
por: Golda, Anna, et al.
Publicado: (2019)

Interaction of Temporin-L Analogues with the E. coli FtsZ Protein
por: Di Somma, Angela, et al.
Publicado: (2021)

Discriminating between competing models for the allosteric regulation of oncogenic phosphatase SHP2 by characterizing its active state
por: Calligari, Paolo, et al.
Publicado: (2021)

From Crystalline to Amorphous Germania Bilayer Films at the Atomic Scale: Preparation and Characterization
por: Lewandowski, Adrián L., et al.
Publicado: (2019)

Engineering of Antimicrobial Surfaces by Using Temporin Analogs to Tune the Biocidal/antiadhesive Effect
por: Oger, Pierre-Carl, et al.
Publicado: (2019)

The Role of Phosphoglycans in the Susceptibility of Leishmania mexicana to the Temporin Family of Anti-Microbial Peptides
por: Eggimann, Gabriela A., et al.
Publicado: (2015)

First-in-Class Cyclic Temporin L Analogue: Design, Synthesis, and Antimicrobial Assessment
por: Bellavita, Rosa, et al.
Publicado: (2021)

Evaluation of the Synthetic Multifunctional Peptide Hp-MAP3 Derivative of Temporin-PTa
por: Silva, Patrícia Souza e, et al.
Publicado: (2023)

Comparison of Anti-Viral Activity of Frog Skin Anti-Microbial Peptides Temporin-Sha and [K(3)]SHa to LL-37 and Temporin-Tb against Herpes Simplex Virus Type 1
por: Roy, Maëva, et al.
Publicado: (2019)

Broad-Spectrum Antiviral Activity of the Amphibian Antimicrobial Peptide Temporin L and Its Analogs
por: Zannella, Carla, et al.
Publicado: (2022)

A Temporin Derived Peptide Showing Antibacterial and Antibiofilm Activities against Staphylococcus aureus
por: An, Meidi, et al.
Publicado: (2023)

Thermodynamics of Peptide Insertion and Aggregation in a Lipid Bilayer
por: Babakhani, Arneh, et al.
Publicado: (2008)

Interaction of Nuclease Colicins with Membranes: Insertion Depth Correlates with Bilayer Perturbation
por: Vankemmelbeke, Mireille, et al.
Publicado: (2012)

Carnitine palmitoyl transferase-1A (CPT1A): a new tumor specific target in human breast cancer
por: Pucci, Sabina, et al.
Publicado: (2016)

NMR Structure of Temporin-1 Ta in Lipopolysaccharide Micelles: Mechanistic Insight into Inactivation by Outer Membrane
por: Saravanan, Rathi, et al.
Publicado: (2013)

The Amphibian Antimicrobial Peptide Temporin B Inhibits In Vitro Herpes Simplex Virus 1 Infection
por: Marcocci, M. E., et al.
Publicado: (2018)

Insight into the mechanism of action of temporin-SHa, a new broad-spectrum antiparasitic and antibacterial agent
por: Raja, Zahid, et al.
Publicado: (2017)

Novel temporin L antimicrobial peptides: promoting self-assembling by lipidic tags to tackle superbugs
por: Bellavita, Rosa, et al.
Publicado: (2020)

In vitro and intracellular activities of frog skin temporins against Legionella pneumophila and its eukaryotic hosts
por: Crépin, Alexandre, et al.
Publicado: (2020)

Structure and Formation Mechanism of Antimicrobial Peptides Temporin B- and L-Induced Tubular Membrane Protrusion
por: Zhang, Shan, et al.
Publicado: (2021)

Lipidation of Temporin-1CEb Derivatives as a Tool for Activity Improvement, Pros and Cons of the Approach
por: Kosikowska-Adamus, Paulina, et al.
Publicado: (2021)

Synthetic Amphipathic β-Sheet Temporin-Derived Peptide with Dual Antibacterial and Anti-Inflammatory Activities
por: Bellavita, Rosa, et al.
Publicado: (2022)

Unveiling the mechanism of action of acylated temporin L analogues against multidrug-resistant Candida albicans
por: Bellavita, Rosa, et al.
Publicado: (2022)

Antimicrobial peptide temporin derivatives inhibit biofilm formation and virulence factor expression of Streptococcus mutans
por: Jiang, Shangjun, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_925onpi8h350rrjkfuavqsqfv2