Synthesis of 5′-GalNAc-Conjugated Oligonucleotides: A Comparison of Solid and Solution-Phase Conjugation Strategies

Antisense oligonucleotides (ASOs) conjugated to triantennary N-acetyl galactosamine (GalNAc) ligands represent an emerging approach to antisense therapy. Our current generation of GalNAc-ASO conjugates link the GalNAc to the 5′-terminus of the ASO. The conjugation reaction can be accomplished using...

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Detalles Bibliográficos
Autores principales: Cedillo, Isaiah, Chreng, Dana, Engle, Elyse, Chen, Lijian, McPherson, Andrew K., Rodriguez, Andrew A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
Materias:
Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6152335/
https://www.ncbi.nlm.nih.gov/pubmed/28809818
http://dx.doi.org/10.3390/molecules22081356

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6152335/
https://www.ncbi.nlm.nih.gov/pubmed/28809818
http://dx.doi.org/10.3390/molecules22081356

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