Synthesis and Evaluation of Novel Benzofuran Derivatives as Selective SIRT2 Inhibitors

A series of benzofuran derivatives were designed and synthesized, and their inhibitory activites were measured against the SIRT1–3. The enzymatic assay showed that all the compounds showed certain anti-SIRT2 activity and selective over SIRT1 and SIRT3 with IC(50) (half maximal inhibitory concentrati...

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Detalles Bibliográficos
Autores principales: Zhou, Yumei, Cui, Huaqing, Yu, Xiaoming, Peng, Tao, Wang, Gang, Wen, Xiaoxue, Sun, Yunbo, Liu, Shuchen, Zhang, Shouguo, Hu, Liming, Wang, Lin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6152376/
https://www.ncbi.nlm.nih.gov/pubmed/28805748
http://dx.doi.org/10.3390/molecules22081348

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6152376/
https://www.ncbi.nlm.nih.gov/pubmed/28805748
http://dx.doi.org/10.3390/molecules22081348

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