Rational Design of Cyclic Antimicrobial Peptides Based on BPC194 and BPC198

A strategy for the design of antimicrobial cyclic peptides derived from the lead compounds c(KKLKKFKKLQ) (BPC194) and c(KLKKKFKKLQ) (BPC198) is reported. First, the secondary β-structure of BPC194 and BPC198 was analyzed by carrying out molecular dynamics (MD) simulations. Then, based on the sequenc...

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Detalles Bibliográficos
Autores principales: Cirac, Anna D., Torné, Maria, Badosa, Esther, Montesinos, Emilio, Salvador, Pedro, Feliu, Lidia, Planas, Marta
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6152393/
https://www.ncbi.nlm.nih.gov/pubmed/28672817
http://dx.doi.org/10.3390/molecules22071054

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6152393/
https://www.ncbi.nlm.nih.gov/pubmed/28672817
http://dx.doi.org/10.3390/molecules22071054

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