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Homology modeling and structure-based design improve hydrophobic interaction chromatography behavior of integrin binding antibodies

Monoclonal antibody (mAb) candidates from high-throughput screening or binding affinity optimization often contain mutations leading to liabilities for further development of the antibody, such as aggregation-prone regions and lack of solubility. In this work, we optimized a candidate integrin α11-b...

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Detalles Bibliográficos
Autores principales: Jetha, Arif, Thorsteinson, Nels, Jmeian, Yazen, Jeganathan, Ajitha, Giblin, Patricia, Fransson, Johan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6152428/
https://www.ncbi.nlm.nih.gov/pubmed/30110240
http://dx.doi.org/10.1080/19420862.2018.1475871