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Homology modeling and structure-based design improve hydrophobic interaction chromatography behavior of integrin binding antibodies
Monoclonal antibody (mAb) candidates from high-throughput screening or binding affinity optimization often contain mutations leading to liabilities for further development of the antibody, such as aggregation-prone regions and lack of solubility. In this work, we optimized a candidate integrin α11-b...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Taylor & Francis
2018
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6152428/ https://www.ncbi.nlm.nih.gov/pubmed/30110240 http://dx.doi.org/10.1080/19420862.2018.1475871 |