Structure Based Prediction of Asparagine Deamidation Propensity in Monoclonal Antibodies

Identification of asparagine (Asn) sites that are prone to deamidation is critical for the development of therapeutic monoclonal antibodies (mAbs). Despite a common chemical degradation pathway, the rates of Asn deamidation can vary dramatically among different sites, and prediction of the sensitive...

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Detalles Bibliográficos
Autores principales: Yan, Qingrong, Huang, Maggie, Lewis, Michael J., Hu, Ping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2018
Materias:
Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6152450/
https://www.ncbi.nlm.nih.gov/pubmed/29958069
http://dx.doi.org/10.1080/19420862.2018.1478646

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6152450/
https://www.ncbi.nlm.nih.gov/pubmed/29958069
http://dx.doi.org/10.1080/19420862.2018.1478646

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