Novel Tacrine-Scutellarin Hybrids as Multipotent Anti-Alzheimer’s Agents: Design, Synthesis and Biological Evaluation

A novel series of 6-chlorotacrine-scutellarin hybrids was designed, synthesized and the biological activity as potential anti-Alzheimer’s agents was assessed. Their inhibitory activity towards human acetylcholinesterase (hAChE) and human butyrylcholinesterase (hBChE), antioxidant activity, ability t...

Descripción completa

Detalles Bibliográficos
Autores principales: Spilovska, Katarina, Korabecny, Jan, Sepsova, Vendula, Jun, Daniel, Hrabinova, Martina, Jost, Petr, Muckova, Lubica, Soukup, Ondrej, Janockova, Jana, Kucera, Tomas, Dolezal, Rafael, Mezeiova, Eva, Kaping, Daniel, Kuca, Kamil
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6152717/
https://www.ncbi.nlm.nih.gov/pubmed/28621747
http://dx.doi.org/10.3390/molecules22061006

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6152717/
https://www.ncbi.nlm.nih.gov/pubmed/28621747
http://dx.doi.org/10.3390/molecules22061006

Ejemplares similares