Determination of Structural Requirements of N-Substituted Tetrahydro-β-Carboline Imidazolium Salt Derivatives Using in Silico Approaches for Designing MEK-1 Inhibitors

Novel N-substituted tetrahydro-β-carboline imidazolium salt derivatives proved to have potent antitumor activity in past research. The Topomer CoMFA and CoMSIA function in Sybyl-X 2.0 software was applied for the identification of important features of N-substituted tetrahydro-β-carboline-imidazoliu...

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Detalles Bibliográficos
Autores principales: Liang, Jingwei, Wang, Mingyang, Li, Xinyang, He, Xin, Cao, Chong, Meng, Fanhao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6152744/
https://www.ncbi.nlm.nih.gov/pubmed/28629184
http://dx.doi.org/10.3390/molecules22061020

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6152744/
https://www.ncbi.nlm.nih.gov/pubmed/28629184
http://dx.doi.org/10.3390/molecules22061020

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