Mechanistic Explanation of the Weak Carbonic Anhydrase’s Esterase Activity

In order to elucidate the elementary mechanism of the promiscuous esterase activity of human carbonic anhydrase (h-CA), we present an accurate theoretical investigation on the hydrolysis of fully-acetylated d-glucose functionalized as sulfamate. This h-CA’s inhibitor is of potential relevance in can...

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Detalles Bibliográficos
Autores principales: Piazzetta, Paolo, Marino, Tiziana, Russo, Nino
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6152773/
https://www.ncbi.nlm.nih.gov/pubmed/28629166
http://dx.doi.org/10.3390/molecules22061009

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6152773/
https://www.ncbi.nlm.nih.gov/pubmed/28629166
http://dx.doi.org/10.3390/molecules22061009

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