Synthesis and Evaluation of Novel 2-Pyrrolidone-Fused (2-Oxoindolin-3-ylidene)methylpyrrole Derivatives as Potential Multi-Target Tyrosine Kinase Receptor Inhibitors

Signaling pathways of VEGFs and PDGFs are crucial in tumor angiogenesis, which is essential in solid tumor progression and metastasis. This study reports our strategy for designing and synthesizing a series of novel 2-pyrrolidone-fused (2-oxoindolin-3-ylidene)methylpyrrole derivatives as potential m...

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Detalles Bibliográficos
Autores principales: Yang, Ting-Hsuan, Lee, Chun-I, Huang, Wen-Hsin, Lee, An-Rong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6152791/
https://www.ncbi.nlm.nih.gov/pubmed/28561780
http://dx.doi.org/10.3390/molecules22060913

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6152791/
https://www.ncbi.nlm.nih.gov/pubmed/28561780
http://dx.doi.org/10.3390/molecules22060913

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