Selective ion permeation involves complexation with carboxylates and lysine in a model human sodium channel

Bacterial and human voltage-gated sodium channels (Na(v)s) exhibit similar cation selectivity, despite their distinct EEEE and DEKA selectivity filter signature sequences. Recent high-resolution structures for bacterial Na(v)s have allowed us to learn about ion conduction mechanisms in these simpler...

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Detalles Bibliográficos
Autores principales: Flood, Emelie, Boiteux, Céline, Allen, Toby W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6152994/
https://www.ncbi.nlm.nih.gov/pubmed/30208027
http://dx.doi.org/10.1371/journal.pcbi.1006398

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6152994/
https://www.ncbi.nlm.nih.gov/pubmed/30208027
http://dx.doi.org/10.1371/journal.pcbi.1006398

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