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Selective ion permeation involves complexation with carboxylates and lysine in a model human sodium channel
Bacterial and human voltage-gated sodium channels (Na(v)s) exhibit similar cation selectivity, despite their distinct EEEE and DEKA selectivity filter signature sequences. Recent high-resolution structures for bacterial Na(v)s have allowed us to learn about ion conduction mechanisms in these simpler...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Public Library of Science
2018
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6152994/ https://www.ncbi.nlm.nih.gov/pubmed/30208027 http://dx.doi.org/10.1371/journal.pcbi.1006398 |