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Succinate and the shortcut to the cure of metformin-induced lactic acidosis
Inhibition of the respiratory chain complex I plays a key role in the pathogenesis of metformin-induced lactic acidosis. In a work recently published in this journal, a novel cell-permeable succinate prodrug (NV118) increased in vitro mitochondrial oxygen consumption coupled with energy production a...
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Springer International Publishing
2018
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6153199/ https://www.ncbi.nlm.nih.gov/pubmed/30251134 http://dx.doi.org/10.1186/s40635-018-0202-5 |