Synaptic phospholipids as a new target for cortical hyperexcitability and E/I balance in psychiatric disorders

Lysophosphatidic acid (LPA) is a synaptic phospholipid, which regulates cortical excitation/inhibition (E/I) balance and controls sensory information processing in mice and man. Altered synaptic LPA signaling was shown to be associated with psychiatric disorders. Here, we show that the LPA-synthesiz...

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Detalles Bibliográficos
Autores principales: Thalman, Carine, Horta, Guilherme, Qiao, Lianyong, Endle, Heiko, Tegeder, Irmgard, Cheng, Hong, Laube, Gregor, Sigurdsson, Torfi, Hauser, Maria Jelena, Tenzer, Stefan, Distler, Ute, Aoki, Junken, Morris, Andrew J., Geisslinger, Gerd, Röper, Jochen, Kirischuk, Sergei, Luhmann, Heiko J., Radyushkin, Konstantin, Nitsch, Robert, Vogt, Johannes
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6153268/
https://www.ncbi.nlm.nih.gov/pubmed/29743582
http://dx.doi.org/10.1038/s41380-018-0053-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6153268/
https://www.ncbi.nlm.nih.gov/pubmed/29743582
http://dx.doi.org/10.1038/s41380-018-0053-1

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