Cargando…
Synaptic phospholipids as a new target for cortical hyperexcitability and E/I balance in psychiatric disorders
Lysophosphatidic acid (LPA) is a synaptic phospholipid, which regulates cortical excitation/inhibition (E/I) balance and controls sensory information processing in mice and man. Altered synaptic LPA signaling was shown to be associated with psychiatric disorders. Here, we show that the LPA-synthesiz...
Autores principales: | Thalman, Carine, Horta, Guilherme, Qiao, Lianyong, Endle, Heiko, Tegeder, Irmgard, Cheng, Hong, Laube, Gregor, Sigurdsson, Torfi, Hauser, Maria Jelena, Tenzer, Stefan, Distler, Ute, Aoki, Junken, Morris, Andrew J., Geisslinger, Gerd, Röper, Jochen, Kirischuk, Sergei, Luhmann, Heiko J., Radyushkin, Konstantin, Nitsch, Robert, Vogt, Johannes |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2018
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6153268/ https://www.ncbi.nlm.nih.gov/pubmed/29743582 http://dx.doi.org/10.1038/s41380-018-0053-1 |
Ejemplares similares
-
Synaptic Phospholipid Signaling Modulates Axon Outgrowth via Glutamate-dependent Ca(2+)-mediated Molecular Pathways
por: Vogt, Johannes, et al.
Publicado: (2017) -
Prevention of age-associated neuronal hyperexcitability with improved learning and attention upon knockout or antagonism of LPAR2
por: Fischer, Caroline, et al.
Publicado: (2020) -
Molecular cause and functional impact of altered synaptic lipid signaling due to a prg‐1 gene SNP
por: Vogt, Johannes, et al.
Publicado: (2015) -
Plasticity-Related Gene 1 Affects Mouse Barrel Cortex Function via Strengthening of Glutamatergic Thalamocortical Transmission
por: Unichenko, Petr, et al.
Publicado: (2016) -
Role of tonic GABAergic currents during pre- and early postnatal rodent development
por: Kilb, Werner, et al.
Publicado: (2013)