Drug Screening Identifies Sigma-1-Receptor as a Target for the Therapy of VWM Leukodystrophy

Vanishing white matter (VWM) disease is an autosomal genetic leukodystrophy caused by mutations in subunits of eukaryotic translation initiation factor 2B (eIF2B). The clinical symptoms exhibit progressive loss of white matter in both hemispheres of the brain, accompanied by motor functions deterior...

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Detalles Bibliográficos
Autores principales: Atzmon, Andrea, Herrero, Melisa, Sharet-Eshed, Reut, Gilad, Yocheved, Senderowitz, Hanoch, Elroy-Stein, Orna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6153319/
https://www.ncbi.nlm.nih.gov/pubmed/30279648
http://dx.doi.org/10.3389/fnmol.2018.00336

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6153319/
https://www.ncbi.nlm.nih.gov/pubmed/30279648
http://dx.doi.org/10.3389/fnmol.2018.00336

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