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Taurodeoxycholate Increases the Number of Myeloid-Derived Suppressor Cells That Ameliorate Sepsis in Mice

Bile acids (BAs) control metabolism and inflammation by interacting with several receptors. Here, we report that intravenous infusion of taurodeoxycholate (TDCA) decreases serum pro-inflammatory cytokines, normalizes hypotension, protects against renal injury, and prolongs mouse survival during seps...

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Detalles Bibliográficos
Autores principales: Chang, Sooghee, Kim, Youn-Hee, Kim, Young-Joo, Kim, Young-Woo, Moon, Sungyoon, Lee, Yong Yook, Jung, Jin Sun, Kim, Youngsoo, Jung, Hi-Eun, Kim, Tae-Joo, Cheong, Taek-Chin, Moon, Hye-Jung, Cho, Jung-Ah, Kim, Hang-Rae, Han, Dohyun, Na, Yirang, Seok, Seung-Hyeok, Cho, Nam-Hyuk, Lee, Hai-Chon, Nam, Eun-Hee, Cho, Hyosuk, Choi, Murim, Minato, Nagahiro, Seong, Seung-Yong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6153344/
https://www.ncbi.nlm.nih.gov/pubmed/30279688
http://dx.doi.org/10.3389/fimmu.2018.01984