Bisarylureas Based on 1H-Pyrazolo[3,4-d]pyrimidine Scaffold as Novel Pan-RAF Inhibitors with Potent Anti-Proliferative Activities: Structure-Based Design, Synthesis, Biological Evaluation and Molecular Modelling Studies

RAF (Ras activating factor) kinases are important and attractive targets for cancer therapy. With the aim of discovering RAF inhibitors that bind to DFG-out inactive conformation created by the movement of Asp-Phe-Gly (DFG), we conducted structure-based drug design using the X-ray cocrystal structur...

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Detalles Bibliográficos
Autores principales: Fu, Yu, Wang, Yuanyuan, Wan, Shanhe, Li, Zhonghuang, Wang, Guangfa, Zhang, Jiajie, Wu, Xiaoyun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6153936/
https://www.ncbi.nlm.nih.gov/pubmed/28353640
http://dx.doi.org/10.3390/molecules22040542

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6153936/
https://www.ncbi.nlm.nih.gov/pubmed/28353640
http://dx.doi.org/10.3390/molecules22040542

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