Loss of the Phenolic Hydroxyl Group and Aromaticity from the Side Chain of Anti-Proliferative 10-Methyl-aplog-1, a Simplified Analog of Aplysiatoxin, Enhances Its Tumor-Promoting and Proinflammatory Activities

Aplysiatoxin (ATX) is a protein kinase C (PKC) activator with potent tumor-promoting activity. In contrast, 10-methyl-aplog-1 (1), a simplified analog of ATX, was anti-proliferative towards several cancer cell lines without significant tumor-promoting and proinflammatory activities. To determine the...

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Detalles Bibliográficos
Autores principales: Hanaki, Yusuke, Kikumori, Masayuki, Tokuda, Harukuni, Okamura, Mutsumi, Dan, Shingo, Adachi, Naoko, Saito, Naoaki, Yanagita, Ryo C., Irie, Kazuhiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6153940/
https://www.ncbi.nlm.nih.gov/pubmed/28406454
http://dx.doi.org/10.3390/molecules22040631

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6153940/
https://www.ncbi.nlm.nih.gov/pubmed/28406454
http://dx.doi.org/10.3390/molecules22040631

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