Discovery and Identification of an Endogenous Metabolite of Tramiprosate and Its Prodrug ALZ-801 that Inhibits Beta Amyloid Oligomer Formation in the Human Brain

BACKGROUND: ALZ-801 is an oral, small-molecule inhibitor of beta amyloid (Aβ) oligomer formation in clinical development for Alzheimer’s disease (AD). ALZ-801 is a prodrug of tramiprosate with improved pharmacokinetic properties and gastrointestinal tolerability. During clinical studies, we discover...

Descripción completa

Detalles Bibliográficos
Autores principales: Hey, John A., Kocis, Petr, Hort, Jakub, Abushakra, Susan, Power, Aidan, Vyhnálek, Martin, Yu, Jeremy Y., Tolar, Martin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2018
Materias:
Original Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6153967/
https://www.ncbi.nlm.nih.gov/pubmed/30076539
http://dx.doi.org/10.1007/s40263-018-0554-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6153967/
https://www.ncbi.nlm.nih.gov/pubmed/30076539
http://dx.doi.org/10.1007/s40263-018-0554-0

Ejemplares similares