Ubiquitin Receptor RPN13 Mediates the Inhibitory Interaction of Diphenyldihaloketones CLEFMA and EF24 With the 26S Proteasome

The proteasome is a validated target in drug discovery for diseases associated with unusual proteasomal activity. Here we report that two diphenyldihaloketones, CLEFMA and EF24, inhibit the peptidase activity of the 26S proteasome. The objective of this study was to investigate interaction of these...

Descripción completa

Detalles Bibliográficos
Autores principales: Rao, Geeta, Nkepang, Gregory, Xu, Jian, Yari, Hooman, Houson, Hailey, Teng, Chengwen, Awasthi, Vibhudutta
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6153970/
https://www.ncbi.nlm.nih.gov/pubmed/30280096
http://dx.doi.org/10.3389/fchem.2018.00392

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6153970/
https://www.ncbi.nlm.nih.gov/pubmed/30280096
http://dx.doi.org/10.3389/fchem.2018.00392

Ejemplares similares