Exploring the Pivotal Role of the CK2 Hinge Region Sub-Pocket in Binding with Tricyclic Quinolone Analogues by Computational Analysis

Protein kinase CK2 has been considered as an attractive therapeutic target of cancer therapy. The tricyclic quinoline compound CX-4945 is the first representative of CK2 inhibitors used in human clinical trials. The binding of non-2,6-naphtyridine substituted compounds 27e (IC(50) > 500 nM) and 2...

Descripción completa

Detalles Bibliográficos
Autores principales: Zhou, Yue, Zhang, Na, Tang, Shan, Qi, Xiaoqian, Zhao, Lijiao, Zhong, Rugang, Peng, Yongzhen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6154313/
https://www.ncbi.nlm.nih.gov/pubmed/28534839
http://dx.doi.org/10.3390/molecules22050840

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6154313/
https://www.ncbi.nlm.nih.gov/pubmed/28534839
http://dx.doi.org/10.3390/molecules22050840

Ejemplares similares