Cargando…

SPAG5 promotes hepatocellular carcinoma progression by downregulating SCARA5 through modifying β-catenin degradation

BACKGROUND: The sperm-associated antigen 5 (SPAG5) plays a key role in controlling various cellular phenomena, including cell cycle progression and proliferation. However, the role of SPAG5 in hepatocellular carcinoma (HCC) remains unknown. METHODS: This study investigated the function and clinical...

Descripción completa

Detalles Bibliográficos
Autores principales:	Liu, Hongliang, Hu, Junwen, Wei, Ran, Zhou, Longfei, Pan, Hua, Zhu, Hongchao, Huang, Mingwen, Luo, Jun, Xu, Wei
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2018
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6154423/ https://www.ncbi.nlm.nih.gov/pubmed/30249289 http://dx.doi.org/10.1186/s13046-018-0891-3

Ejemplares similares

SCARA5 Is Overexpressed in Prostate Cancer and Linked to Poor Prognosis
por: Flockerzi, Fidelis Andrea, et al.
Publicado: (2023)

Methylation analysis of p16, SLIT2, SCARA5, and Runx3 genes in hepatocellular carcinoma
por: Sun, Gaofeng, et al.
Publicado: (2017)

SPAG5‐AS1 inhibited autophagy and aggravated apoptosis of podocytes via SPAG5/AKT/mTOR pathway
por: Xu, Jun, et al.
Publicado: (2020)

SPAG5, the upstream protein of Wnt and the target of curcumin, inhibits hepatocellular carcinoma
por: Li, Huiyang, et al.
Publicado: (2023)

SCARA5 plays a critical role in the commitment of mesenchymal stem cells to adipogenesis
por: Lee, Hyemin, et al.
Publicado: (2017)

SCARA5 inhibits gastric cancer progression via epithelial-mesenchymal transition suppression
por: Zhang, Hangyu, et al.
Publicado: (2021)

Highly Expressing SCARA5 Promotes Proliferation and Migration of Esophageal Squamous Cell Carcinoma
por: Jumai, Kawuli, et al.
Publicado: (2022)

SCARA5 induced ferroptosis to effect ESCC proliferation and metastasis by combining with Ferritin light chain
por: Liu, Yanqun, et al.
Publicado: (2022)

Decreased expression of SCARA5 predicts a poor prognosis in melanoma using bioinformatics analysis
por: Ni, Qinggan, et al.
Publicado: (2023)

CircFOXM1 promotes proliferation and metastasis of hepatocellular carcinoma via regulating miR-1179/SPAG5 axis
por: Wang, Gaoqing, et al.
Publicado: (2021)

Fe-doped chrysotile nanotubes containing siRNAs to silence SPAG5 to treat bladder cancer
por: Liu, Jianye, et al.
Publicado: (2021)

L-Ferritin Binding to Scara5: A New Iron Traffic Pathway Potentially Implicated in Retinopathy
por: Mendes-Jorge, Luísa, et al.
Publicado: (2014)

Suppression of SCARA5 by Snail1 is essential for EMT-associated cell migration of A549 cells
por: Liu, J, et al.
Publicado: (2013)

The Novel Methylation Biomarker SCARA5 Sensitizes Cancer Cells to DNA Damage Chemotherapy Drugs in NSCLC
por: Peng, Qi, et al.
Publicado: (2021)

BMSC-derived exosomal lncRNA PTENP1 suppresses the malignant phenotypes of bladder cancer by upregulating SCARA5 expression
por: Liu, Shu-Cheng, et al.
Publicado: (2022)

Identification of SCARA3 with potential roles in metabolic disorders
por: Peng, Hui, et al.
Publicado: (2020)

SPAG5 Is Involved in Human Gliomagenesis Through the Regulation of Cell Proliferation and Apoptosis
por: Wang, Chunhong, et al.
Publicado: (2021)

Correction: L-Ferritin Binding to Scara5: A New Iron Traffic Pathway Potentially Implicated in Retinopathy
por: Mendes-Jorge, Luísa, et al.
Publicado: (2017)

SPAG5 interacts with CEP55 and exerts oncogenic activities via PI3K/AKT pathway in hepatocellular carcinoma
por: Yang, Yu-Feng, et al.
Publicado: (2018)

The mitotic spindle protein SPAG5/Astrin connects to the Usher protein network postmitotically
por: Kersten, Ferry FJ, et al.
Publicado: (2012)

miR-539 inhibits prostate cancer progression by directly targeting SPAG5
por: Zhang, Hongtuan, et al.
Publicado: (2016)

The prognostic association of SPAG5 gene expression in breast cancer patients with systematic therapy
por: Zhu, Chenjing, et al.
Publicado: (2019)

SCARA5 suppresses the proliferation and migration, and promotes the apoptosis of human retinoblastoma cells by inhibiting the PI3K/AKT pathway
por: Wang, Jinwei, et al.
Publicado: (2021)

SPAG5 Expression Predicts Poor Prognosis and is Associated With Adverse Immune Infiltration in Lung Adenocarcinomas
por: Xiao, Gang, et al.
Publicado: (2023)

SCARA5 inhibits oral squamous cell carcinoma via inactivating the STAT3 and PI3K/AKT signaling pathways
por: Huang, Juan, et al.
Publicado: (2023)

The interactome of CLUH reveals its association to SPAG5 and its co-translational proximity to mitochondrial proteins
por: Hémono, Mickaële, et al.
Publicado: (2022)

SPAG17 Is Required for Male Germ Cell Differentiation and Fertility
por: Kazarian, Elizabeth, et al.
Publicado: (2018)

Targeting protein arginine methyltransferase 5 inhibits human hepatocellular carcinoma growth via the downregulation of beta-catenin
por: Zhang, Baolai, et al.
Publicado: (2015)

The splicing factor SF3B4 drives proliferation and invasion in cervical cancer by regulating SPAG5
por: Li, Yingwei, et al.
Publicado: (2022)

SCARA3 inhibits cell proliferation and EMT through AKT signaling pathway in lung cancer
por: Kim, Jeeho, et al.
Publicado: (2022)

SPAG5 is associated with unfavorable prognosis in patients with lung adenocarcinoma and promotes proliferation, motility and autophagy in A549 cells
por: Huang, Ruijia, et al.
Publicado: (2020)

Investigation of the SPAG5 gene expression and amplification related to the NuMA mRNA levels in breast ductal carcinoma
por: Mohamadalizadeh-Hanjani, Zeinab, et al.
Publicado: (2020)

Spag17 Deficiency Results in Skeletal Malformations and Bone Abnormalities
por: Teves, Maria Eugenia, et al.
Publicado: (2015)

SPAG17 mediates nuclear translocation of protamines during spermiogenesis
por: Agudo-Rios, Clara, et al.
Publicado: (2023)

Scara1 deficiency impairs clearance of soluble Amyloid-β by mononuclear phagocytes and accelerates Alzheimer’s-like disease progression
por: Frenkel, Dan, et al.
Publicado: (2013)

Spag16, an Axonemal Central Apparatus Gene, Encodes a Male Germ Cell Nuclear Speckle Protein that Regulates SPAG16 mRNA Expression
por: Nagarkatti-Gude, David R., et al.
Publicado: (2011)

Neurofuzzy c-Means Network-Based SCARA Robot for Head Gimbal Assembly (HGA) Circuit Inspection
por: Kiatwanidvilai, Somyot, et al.
Publicado: (2018)

Carcinoma-associated fibroblasts release microRNA-331-3p containing extracellular vesicles to exacerbate the development of pancreatic cancer via the SCARA5-FAK axis
por: Han, Yadong, et al.
Publicado: (2022)

GSTZ1‐1 downregulates Wnt/β‐catenin signalling in hepatocellular carcinoma cells
por: Lei, Chong, et al.
Publicado: (2019)

Correlation of Sperm Associated Antigen 11 (SPAG11) and its Isoforms with Varicocele in Rats
por: Tian, Hong, et al.
Publicado: (2012)

Cannot write session to /tmp/vufind_sessions/sess_rn8j9ehe24tu21u5j2runq3oj6