Glycemic Variability Promotes Both Local Invasion and Metastatic Colonization by Pancreatic Ductal Adenocarcinoma

BACKGROUND & AIMS: Although nearly half of pancreatic ductal adenocarcinoma (PDAC) patients have diabetes mellitus with episodes of hyperglycemia, its tumor microenvironment is hypoglycemic. Thus, it is crucial for PDAC cells to develop adaptive mechanisms dealing with oscillating glucose levels...

Descripción completa

Detalles Bibliográficos
Autores principales: Jian, Ziying, Cheng, Tao, Zhang, Zhiheng, Raulefs, Susanne, Shi, Kuangyu, Steiger, Katja, Maeritz, Nadja, Kleigrewe, Karin, Hofmann, Thomas, Benitz, Simone, Bruns, Philipp, Lamp, Daniel, Jastroch, Martin, Akkan, Jan, Jäger, Carsten, Huang, Peilin, Nie, Shuang, Shen, Shanshan, Zou, Xiaoping, Ceyhan, Güralp O., Michalski, Christoph W., Friess, Helmut, Kleeff, Jörg, Kong, Bo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2018
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6154439/
https://www.ncbi.nlm.nih.gov/pubmed/30258965
http://dx.doi.org/10.1016/j.jcmgh.2018.07.003

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6154439/
https://www.ncbi.nlm.nih.gov/pubmed/30258965
http://dx.doi.org/10.1016/j.jcmgh.2018.07.003

Ejemplares similares