Design, Synthesis, Molecular Docking Analysis, and Carbonic Anhydrase IX Inhibitory Evaluations of Novel N-Substituted-β-d-Glucosamine Derivatives that Incorporate Benzenesulfonamides

A series of novel N-substituted-β-d-glucosamine derivatives that incorporate benzenesulfonamides were designed using a fragment-based drug design strategy. Each derivative was synthesized and evaluated in vitro for its inhibitory activity against human carbonic anhydrase (hCA) IX; several derivative...

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Detalles Bibliográficos
Autores principales: Li, Feng-Ran, Fan, Zhan-Fang, Qi, Su-Jiao, Wang, Yan-Shi, Wang, Jian, Liu, Yang, Cheng, Mao-Sheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6154466/
https://www.ncbi.nlm.nih.gov/pubmed/28498332
http://dx.doi.org/10.3390/molecules22050785

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6154466/
https://www.ncbi.nlm.nih.gov/pubmed/28498332
http://dx.doi.org/10.3390/molecules22050785

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