An Expedient Total Synthesis of Triciribine

In the present paper, we report an expedient total synthesis of triciribine, a tricyclic 7-deazapurine nucleoside and protein kinase B (AKT ) inhibitor, in 35% overall yield. Our synthesis route features a highly regioselective substitution of 1-N-Boc-2-methylhydrazine and a trifluoroacetic acid cat...

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Detalles Bibliográficos
Autores principales: Hu, Chen, Ruan, Zhizhong, Ding, Haixin, Zhou, Yirong, Xiao, Qiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
Materias:
Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6154533/
https://www.ncbi.nlm.nih.gov/pubmed/28420174
http://dx.doi.org/10.3390/molecules22040643

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6154533/
https://www.ncbi.nlm.nih.gov/pubmed/28420174
http://dx.doi.org/10.3390/molecules22040643

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