Discovery and Biological Evaluation of a Series of Pyrrolo[2,3-b]pyrazines as Novel FGFR Inhibitors

Abnormality of fibroblast growth factor receptor (FGFR)-mediated signaling pathways were frequently found in various human malignancies, making FGFRs hot targets for cancer treatment. To address the consistent need for a new chemotype of FGFR inhibitors, here, we started with a hit structure identif...

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Detalles Bibliográficos
Autores principales: Zhang, Yan, Liu, Hongchun, Zhang, Zhen, Wang, Ruifeng, Liu, Tongchao, Wang, Chaoyun, Ma, Yuchi, Ai, Jing, Zhao, Dongmei, Shen, Jingkang, Xiong, Bing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6154558/
https://www.ncbi.nlm.nih.gov/pubmed/28379191
http://dx.doi.org/10.3390/molecules22040583

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6154558/
https://www.ncbi.nlm.nih.gov/pubmed/28379191
http://dx.doi.org/10.3390/molecules22040583

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