Adenosine A1 and A2A Receptors in the Brain: Current Research and Their Role in Neurodegeneration

The inhibitory adenosine A1 receptor (A1R) and excitatory A2A receptor (A2AR) are predominantly expressed in the brain. Whereas the A2AR has been implicated in normal aging and enhancing neurotoxicity in multiple neurodegenerative diseases, the inhibitory A1R has traditionally been ascribed to have...

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Autores principales: Stockwell, Jocelyn, Jakova, Elisabet, Cayabyab, Francisco S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6154612/
https://www.ncbi.nlm.nih.gov/pubmed/28441750
http://dx.doi.org/10.3390/molecules22040676
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author Stockwell, Jocelyn
Jakova, Elisabet
Cayabyab, Francisco S.
author_facet Stockwell, Jocelyn
Jakova, Elisabet
Cayabyab, Francisco S.
author_sort Stockwell, Jocelyn
collection PubMed
description The inhibitory adenosine A1 receptor (A1R) and excitatory A2A receptor (A2AR) are predominantly expressed in the brain. Whereas the A2AR has been implicated in normal aging and enhancing neurotoxicity in multiple neurodegenerative diseases, the inhibitory A1R has traditionally been ascribed to have a neuroprotective function in various brain insults. This review provides a summary of the emerging role of prolonged A1R signaling and its potential cross-talk with A2AR in the cellular basis for increased neurotoxicity in neurodegenerative disorders. This A1R signaling enhances A2AR-mediated neurodegeneration, and provides a platform for future development of neuroprotective agents in stroke, Parkinson’s disease and epilepsy.
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spelling pubmed-61546122018-11-13 Adenosine A1 and A2A Receptors in the Brain: Current Research and Their Role in Neurodegeneration Stockwell, Jocelyn Jakova, Elisabet Cayabyab, Francisco S. Molecules Review The inhibitory adenosine A1 receptor (A1R) and excitatory A2A receptor (A2AR) are predominantly expressed in the brain. Whereas the A2AR has been implicated in normal aging and enhancing neurotoxicity in multiple neurodegenerative diseases, the inhibitory A1R has traditionally been ascribed to have a neuroprotective function in various brain insults. This review provides a summary of the emerging role of prolonged A1R signaling and its potential cross-talk with A2AR in the cellular basis for increased neurotoxicity in neurodegenerative disorders. This A1R signaling enhances A2AR-mediated neurodegeneration, and provides a platform for future development of neuroprotective agents in stroke, Parkinson’s disease and epilepsy. MDPI 2017-04-23 /pmc/articles/PMC6154612/ /pubmed/28441750 http://dx.doi.org/10.3390/molecules22040676 Text en © 2017 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Stockwell, Jocelyn
Jakova, Elisabet
Cayabyab, Francisco S.
Adenosine A1 and A2A Receptors in the Brain: Current Research and Their Role in Neurodegeneration
title Adenosine A1 and A2A Receptors in the Brain: Current Research and Their Role in Neurodegeneration
title_full Adenosine A1 and A2A Receptors in the Brain: Current Research and Their Role in Neurodegeneration
title_fullStr Adenosine A1 and A2A Receptors in the Brain: Current Research and Their Role in Neurodegeneration
title_full_unstemmed Adenosine A1 and A2A Receptors in the Brain: Current Research and Their Role in Neurodegeneration
title_short Adenosine A1 and A2A Receptors in the Brain: Current Research and Their Role in Neurodegeneration
title_sort adenosine a1 and a2a receptors in the brain: current research and their role in neurodegeneration
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6154612/
https://www.ncbi.nlm.nih.gov/pubmed/28441750
http://dx.doi.org/10.3390/molecules22040676
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